![]() ![]() Chromium is also present in many multivitamin/mineral supplements, and there are also specific chromium picolinate (CrP) supplements that contain 200–600 μg chromium per tablet ( 10). Trivalent chromium is found in a wide range of foods, including egg yolks, whole-grain products, high-bran breakfast cereals, coffee, nuts, green beans, broccoli, meat, brewer’s yeast, and some brands of wine and beer ( 8, 9). Chromium is now routinely added to TPN solutions ( 5). Other studies ( 4, 5) of the beneficial effects of chromium in patients receiving TPN have also been documented in the scientific literature. In the following 2 weeks, signs and symptoms of diabetes were ameliorated, with markedly improved glycemic status and greatly reduced insulin requirements (exogenous insulin requirements decreased from 45 units/day to none). Based on previous animal studies and preliminary human studies, the patient was given supplemental chromium. A patient receiving total parenteral nutrition (TPN) developed severe signs of diabetes, including weight loss and hyperglycemia that was refractory to increasing insulin dosing ( 3). Interest regarding chromium administration in patients with diabetes was kindled by the observation in the 1970s that it truly was an essential nutrient required for normal carbohydrate metabolism. ![]() This factor was eventually suggested to be a biologically active form of trivalent chromium that could substantially lower plasma glucose levels in diabetic mice ( 2). The interest in chromium as a nutritional enhancement to glucose metabolism can be traced back to the 1950s, when it was suggested that brewer’s yeast contained a glucose tolerance factor (GTF) that prevented diabetes in experimental animals ( 1). ![]()
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